Heme oxygenase-1 derived carbon monoxide suppresses Aβ1–42 toxicity in astrocytes
نویسندگان
چکیده
منابع مشابه
Heme oxygenase-1 derived carbon monoxide suppresses Aβ1–42 toxicity in astrocytes
Neurodegeneration in Alzheimer's disease (AD) is extensively studied, and the involvement of astrocytes and other cell types in this process has been described. However, the responses of astrocytes themselves to amyloid β peptides ((Aβ; the widely accepted major toxic factor in AD) is less well understood. Here, we show that Aβ(1-42) is toxic to primary cultures of astrocytes. Toxicity does not...
متن کاملHeme Oxygenase-1 and Carbon Monoxide in the Heart
Self-preservation is a fundamental tenet exhibited by all organisms and is perhaps most apparent when the organism is confronted by various threats to survival. This concept also holds true at the most basic cellular level where the cell coordinates a series of responses evolved to ensure the best chance of defense and survival. The ability of cells and tissues to mount an adaptive response to ...
متن کاملHeme oxygenase-1 and carbon monoxide in pulmonary medicine
Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stress in vitro and in vivo. In addition to its physiological role in heme degradation, HO-1 may influence a number of cellular processes, including growth, inflammation, and apoptosis. By virtue of anti-inflammatory effects, HO-1 limits tissue damage in response to proinflammatory stimuli and prevent...
متن کاملCytoprotection of heme oxygenase-1/carbon monoxide in lung injury.
Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) have been the major cause of morbidity and mortality in intensive care units (ICU) over the past decades despite advances in therapeutic modalities. This syndrome is characterized by noncardiogenic pulmonary edema, and pulmonary and systemic inflammation resulting in respiratory failure (1, 2). Both exudative and proliferati...
متن کاملCarbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
Heme oxygenase 1 (HO-1) inhibits apoptosis by regulating cellular prooxidant iron. We now show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by generating the gaseous molecule carbon monoxide (CO). Overexpression of HO-1, or induction of HO-1 expression by heme, protects endothelial cells (ECs) from apoptosis. When HO-1 enzymatic activity is blocked by tin proto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2017
ISSN: 2041-4889
DOI: 10.1038/cddis.2017.276